Dr. Anand Srinivasan

Dr. Anand Srinivasan

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Pharmacology

pharm_anand@aiimsbhubaneswar.edu.in

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Dr. Anand Srinivasan

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Pharmacology

Degree / Diploma Name of the University/ Institution Subject Year of Passing
MBBS 2007 Government Coimbatore Medical College, Coimbatore
MD (Pharmacology) 2011 Postgraduate Institute of Medical Education and Research, Chandigarh
DM (Clinical Pharmacology) 2015 Postgraduate Institute of Medical Education and Research, Chandigarh
  • Artificial Intelligence
  • Precision Medicine
  • Computational Medicine
  • Pharmacometrics and Clinical Trials

  • Ramasubbu MK, Hota D, Das Majumdar Sk, Parida DK, Mukherjee P, Srinivasan A. A group sequential response-adaptive randomized double-blinded clinical trial to evaluate the safety and efficacy of add-on olanzapine plus pregabalin for the prevention of chemotherapy-induced nausea and vomiting. Supportive Care in Cancer 2025; 33(3): 203.
  • Mishra A, Mishra BR, Mohapatra D, Srinivasan A, Maiti R, Hota D. Carbamazepine toxicity with concomitant levetiracetam therapy in patients with epilepsy. International Journal of Neuroscience 2025; (just-accepted): 1-10.
  • Kumar SK, Misra S, Behera BK, Singh N, Muduly DK, Srinivasan A. The effect of intraoperative low-dose ketamine versus dexmedetomidine infusion on postoperative bowel recovery in patients undergoing gastrointestinal malignancy surgeries: Placebo-controlled, randomized trial. Journal of Anaesthesiology Clinical Pharmacology 2025; 41(1): 145-50.
  • Hota D, Srinivasan A, Panigrahi MK, Dalua SS, Tiwari P, Valavan R. A clinical study on the efficacy and safety of poly-herbal formulation in managing functional dyspepsia. Phytomedicine Plus 2025; 5(1): 100671.
  • Balagod R, Tripathy SK, Pradhan SS, et al. Early Intra-articular Hyaluronic Acid Injection After Anterior Cruciate Ligament Reconstruction Provides Short-Term Pain Relief and Improves Early Postoperative Function With No Clinical Benefits at 6 and 12 Months: A Randomized Controlled Trial. Arthroscopy: The Journal of Arthroscopic & Related Surgery 2025.
  • Tripathy SK, Das Majumdar S, Pradhan SS, Varghese P, Behera H, Srinivasan A. A Short Course of Preoperative Denosumab Injection Followed by Surgery in High-Risk Giant Cell Tumors of the Extremities: A Retrospective Study. Indian Journal of Surgical Oncology 2024; 15(4): 825-36.
  • Srinivasan A, Mishra A, Hota D. Why R Is Essential? What Are the Prospects of Learning R? R for Basic Biostatistics in Medical Research: Springer; 2024: 1-4.
  • Srinivasan A, Mishra A. Receiver Operating Characteristic (ROC) Curve Analysis for Diagnostic Studies. R for Basic Biostatistics in Medical Research: Springer; 2024: 253-8.
  • Srinivasan A, Maiti R, Mishra A. Computation of Sample Size for Clinical Studies. R for Basic Biostatistics in Medical Research: Springer; 2024: 199-209.
  • Singh I, Srinivasan A, Mishra A. Inferential Statistics for Hypothesis Testing of Parametrically Distributed Data. R for Basic Biostatistics in Medical Research: Springer; 2024: 119-56.
  • Ramasubbu MK, Paleja B, Srinivasann A, Maiti R, Kumar R. Applying quantitative and systems pharmacology to drug development and beyond: An introduction to clinical pharmacologists. Indian Journal of Pharmacology 2024; 56(4): 268-76.
  • Padmanabhan G, Mishra A, Srinivasan A. Introduction to R Environment and Basic Commands. R for Basic Biostatistics in Medical Research: Springer; 2024: 15-27.
  • Padmanaban G, Mishra A, Srinivasan A. Survival Analysis for Time to Event-Based Outcome. R for Basic Biostatistics in Medical Research: Springer; 2024: 259-68.
  • Padmanaban G, Mishra A, Srinivasan A. Logistic Regression Analysis for Categorical Outcome. R for Basic Biostatistics in Medical Research: Springer; 2024: 235-51.
  • Mishra A, Srinivasan A, Maiti R. An Overview of Statistical Analysis Plan for Clinical Studies. R for Basic Biostatistics in Medical Research 2024: 5-13.
  • Mishra A, Singh I, Srinivasan A. Data Handling and Manipulation in R with Descriptive Statistics. R for Basic Biostatistics in Medical Research: Springer; 2024: 29-62.
  • Mishra A, Maiti R, Mishra BR, Srinivasan A. Efficacy of pharmacological agents for the management of treatment-resistant schizophrenia: a network meta-analysis. Expert Review of Clinical Pharmacology 2024; 17(3): 293-302.
  • Mishra A, Maiti R, Mishra BR, Srinivasan A. Pharmacological agents for TRSEfficacy of pharmacological agents for the management of treatment-resistant schizophrenia: a network meta-analysis. Expert Review of Clinical Pharmacology 2024.
  • Mishra A, Maiti R, kumar Ramasubbu M, Srinivasan A. Evaluation of the pharmacodynamic interaction effect of augmentation agents with clozapine in patients with treatment-resistant schizophrenia: A simulation study of clinical data. Psychiatry Research 2024; 338: 115989.
  • Mishra A, Jena SK, Srinivasan A, Tripathy A, Maiti R, Hota D. Effect of an Add-On Multi-Strain Probiotic Formulation in the Prevention of Recurrent Urinary Tract Infections: A Double-Blind Randomized Placebo-Controlled Trial. Microbiology Research 2024; 15(4): 2330-40.
  • Maji S, Mohapatra D, Jena M, Srinivasan A, Maiti R. Repurposing of dextromethorphan as an adjunct therapy in patients with major depressive disorder: a randomised, group sequential adaptive design, controlled clinical trial protocol. BMJ open 2024; 14(4): e080500.
  • Maji S, Mishra A, Mohapatra D, et al. Early augmentation therapy with dextromethorphan in mild to moderate major depressive disorder: A group sequential, response adaptive randomized controlled trial. Psychiatry Research 2024; 342: 116257.
  • Kumar-M P, Srinivasan A. Visualization of Data: Basic and Advanced. R for Basic Biostatistics in Medical Research: Springer; 2024: 75-118.
  • Krishna MBN, Seetharam JC, Mishra A, Maiti R, Mishra BR, Srinivasan A. Total valproate versus free valproate in therapeutic drug monitoring for bipolar disorder: A cross‐sectional study. Asia‐Pacific Psychiatry 2024; 16(2): e12555.
  • Kimi S, Maiti R, Srinivasan A, Mishra BR, Hota D. Efficacy and safety of V1a receptor antagonists in autism spectrum disorder: A meta‐analysis. International Journal of Developmental Neuroscience 2024; 84(1): 3-13.
  • Hegde NC, Mishra A, Maiti R, Mishra BR, Mohapatra D, Srinivasan A. Pharmacological interventions for antipsychotic-induced weight gain in schizophrenia: A network meta-analysis. General hospital psychiatry 2024; 90: 12-21.
  • Tripathy SK, Varghese P, Panigrahi S, Panda BB, Srinivasan A, Sen RK. Perioperative mortality and morbidity of hip fractures among COVID-19 infected and non-infected patients: A systematic review and meta-analysis. Chinese Journal of Traumatology 2023; 26(03): 162-73.
  • Sethuramalingam S, Maiti R, Hota D, Srinivasan A. Effect of colchicine in reducing inflammatory biomarkers and cardiovascular risk in coronary artery disease: A meta-analysis of clinical trials. LWW; 2023. p. e197-e208.
  • Misra S, Das PK, Srinivasan A. Performance of the transoesophageal echocardiography probe as an oesophageal temperature monitor in patients undergoing cardiac surgery with cardiopulmonary bypass: a prospective observational study. European Journal of Cardio-Thoracic Surgery 2023; 64(2): ezad242.
  • Mishra A, Maiti R, Mishra BR, Srinivasan A. Augmentation Strategies for Partial or Non-responders to Clozapine in Patients with Schizophrenia: A Bayesian Network Meta-analysis of Randomized Controlled Trials. Clinical Psychopharmacology and Neuroscience 2023; 22(2): 232.
  • Maiti R, Mishra A, Srinivasan A, Mishra BR. Pharmacological augmentation of serotonin reuptake inhibitors in patients with obsessive–compulsive disorder: A network meta‐analysis. Acta Psychiatrica Scandinavica 2023; 148(1): 19-31.
  • Haridas MP, Tripathy A, Maiti R, Srinivasan A. Efficacy and safety of anti-CGRP monoclonal antibodies in prevention of chronic migraine: a Bayesian network meta-analysis. Clinical Psychopharmacology and Neuroscience 2023; 22(1): 23.
  • Behera K, Sahu S, Agrawal K, Soren UK, Parida GK, Srinivasan A. Study of Correlation between Serum Osteoprotegerin, TNF-Alfa, and Biomarkers of Bone Metabolism in Patients with Treatment-Naive Graves’ Disease—A Cross-Sectional Study. Indian journal of endocrinology and metabolism 2023; 27(1): 62-5.
  • Sahoo AK, Misra S, Behera BK, Srinivasan A, Jena SS, Mohanty MK. Subanesthetic intravenous ketamine vs. caudal bupivacaine for postoperative analgesia in children undergoing infra-umbilical surgeries: a non-inferiority randomized, single-blind controlled trial. Korean Journal of Anesthesiology 2022; 75(2): 178-84.
  • Ramasubbu MK, Maji S, Padhan M, et al. Chemotherapy-induced hand foot syndrome: comparative efficacy and safety of pharmacological prophylaxis–systematic review and Bayesian network meta-analysis. BMJ Supportive & Palliative Care 2022; 14(e2): e1575-e84.
  • Pradhan SS, Tripathy SK, Jain M, Behera H, Velagada S, Srinivasan A. Impact of limb length discrepancy on functional outcome in total knee arthroplasty patients: a prospective cohort study. Arthroplasty 2022; 4(1): 22.
  • Meher BR, Padhy BM, Srinivasan A, Mohanty RR. Awareness, attitude, and practice of materiovigilance among medical professionals at a tertiary care institute of national importance: A cross-sectional study. Perspectives in Clinical Research 2022; 13(2): 94-8.
  • Meher BR, Mohanty RR, Sahoo JP, et al. Comparative study of the effects of azilsartan and telmisartan on insulin resistance and metabolic biomarkers in essential hypertension associated with type 2 diabetes mellitus. Cureus 2022; 14(2).
  • Bonga KN, Mishra A, Maiti R, Padhy BM, Meher BR, Srinivasan A. Efficacy and safety of fezolinetant for the treatment of menopause-associated vasomotor symptoms: a meta-analysis. Obstetrics & Gynecology 2022: 10-1097.
  • Tripathy SK, Varghese P, Srinivasan A, et al. Joint awareness after unicompartmental knee arthroplasty and total knee arthroplasty: a systematic review and meta‐analysis of cohort studies. Knee Surgery, Sports Traumatology, Arthroscopy 2021; 29(10): 3478-87.
  • Tripathy SK, Varghese P, Panigrahi S, Panda BB, Srinivasan A, Sen RK. External fixation versus open reduction and internal fixation in the treatment of Complex Tibial Plateau Fractures: A systematic review and meta-analysis. Acta Orthop Traumatol Turc 2021; 55(5): 444-56.
  • Srinivasan A, Dutta P, Bansal D, Chakrabarti A, Bhansali AK, Hota D. Efficacy and safety of low‐dose naltrexone in painful diabetic neuropathy: A randomized, double‐blind, active‐control, crossover clinical trial. Journal of Diabetes 2021; 13(10): 770-8.
  • Misra S, Srinivasan A, Jena SS, Bellapukonda S. Myocardial protection in adult cardiac surgery with del Nido versus blood cardioplegia: a systematic review and meta-analysis. Heart, Lung and Circulation 2021; 30(5): 642-55.
  • Misra S, Behera BK, Mitra JK, Sahoo AK, Jena SS, Srinivasan A. Effect of preoperative dexmedetomidine nebulization on the hemodynamic response to laryngoscopy and intubation: a randomized control trial. Korean journal of anesthesiology 2021; 74(2): 150-7.
  • Mishra P, Patra S, Srinivasan A, et al. Primary gastrointestinal anaplastic large cell lymphoma: A critical reappraisal with a systematic review of the world literature. Journal of Cancer Research and Therapeutics 2021; 17(6): 1307-13.
  • Maiti R, Mishra A, Puliappadamb HM, Jena M, Srinivasan A. Efficacy and Safety of Lasmiditan for Acute Treatment of Migraine in Adults: A Meta‐Analysis. The Journal of Clinical Pharmacology 2021; 61(12): 1534-44.
  • Howard C, Sheridan J, Picca L, et al. TEVAR for complicated and uncomplicated type B aortic dissection—Systematic review and meta‐analysis. Journal of cardiac surgery 2021; 36(10): 3820-30.
  • Behera BK, Misra S, Mohanty MK, Srinivasan A. Effect of intra-operative high inspired fraction of oxygen on postoperative nausea and vomiting in children undergoing surgery: A prospective randomised double-blind study. European Journal of Anaesthesiology| EJA 2021; 38(11): 1124-9.
  • Tripathy SK, Rao PB, Nanda SN, et al. Safety and efficacy of epsilon aminocaproic acid (EACA) as an antihemorrhagic drug in bilateral one stage total knee arthroplasty: A double-blind randomized controlled trial. The Knee 2020; 27(1): 229-34.
  • Tripathy SK, Gantaguru A, Nanda SN, Velagada S, Srinivasan A, Mangaraj M. Association of vitamin D and knee osteoarthritis in younger individuals. World journal of orthopedics 2020; 11(10): 418.
  • Tripathy A, Maiti R, Jena M, Mishra A, Srinivasan A. Effect of alpha agonists on the prevention of postparacentesis circulatory dysfunction in patients with refractory or recurrent ascites: a meta-analysis. European Journal of Gastroenterology & Hepatology 2020; 32(3): 303-11.
  • Mishra A, Maiti R, Mishra BR, Jena M, Srinivasan A. Effect of repetitive transcranial magnetic stimulation on seizure frequency and epileptiform discharges in drug-resistant epilepsy: a meta-analysis. Journal of Clinical Neurology 2020; 16(1): 9-18.
  • Meher BR, Srinivasan A, Vighnesh CS, Padhy BM, Mohanty RR. Factors most influencing antibiotic stewardship program and comparison of prefinal-and final-year undergraduate medical students. Perspectives in Clinical Research 2020; 11(1): 18-23.
  • Hota D, Srinivasan A, Sahoo JP, Behera KK, Patro BK, Bandyopadhyay D. Possible Anti-Diabetic and Anti-Hyperlipidemic Efficacy of Blended Rice Bran Oil with Sesame Oil in Comparison with Soybean Oil: A Clinical Investigation in Pre-Diabetic and Diabetic Individuals. J Clin Trials 2020; 10(419): 2167-0870.
  • Behera KK, Saharia GK, Hota D, Sahoo DP, Sethy M, Srinivasan A. Effect of Vitamin D supplementation on thyroid autoimmunity among subjects of autoimmune thyroid disease in a coastal province of India: A randomized open-label trial. Nigerian Medical Journal 2020; 61(5): 237-40.
  • Kirtania L, Maiti R, Srinivasan A, Mishra A. Effect of combination therapy of endothelin receptor antagonist and phosphodiesterase-5 inhibitor on clinical outcome and pulmonary haemodynamics in patients with pulmonary arterial hypertension: a meta-analysis. Clinical drug investigation 2019; 39: 1031-44.
  • Jena M, Ranjan R, Mishra BR, et al. Effect of lurasidone vs olanzapine on neurotrophic biomarkers in unmedicated schizophrenia: A randomized controlled trial. Journal of psychiatric research 2019; 112: 1-6.
  • Yelamanchi SD, Tyagi A, Mohanty V, et al. Proteomic analysis of the human anterior pituitary gland. OMICS: A Journal of Integrative Biology 2018; 22(12): 759-69.
  • Maiti R, Mishra BR, Jena M, Mishra A, Nath S, Srinivasan A. Effect of anti-seizure drugs on serum S100B in patients with focal seizure: a randomized controlled trial. Journal of neurology 2018; 265: 2594-601.
  • Kumar-M P, Garg N, Srinivasan A, Saha S, Sharma S, Medhi B. Shyam’s Chromatography and TDM Server in R Shiny-An Open-Source Program for TDM Laboratories. Available at SSRN 4317484 2018.
  • Gupta P, Rai A, Mukherjee KK, et al. Imatinib inhibits GH secretion from somatotropinomas. Frontiers in endocrinology 2018; 9: 453.
  • Maiti R, Sirka CS, Ashique Rahman MA, Srinivasan A, Parida S, Hota D. Efficacy and safety of tazarotene 0.1% plus clindamycin 1% gel versus adapalene 0.1% plus clindamycin 1% gel in facial acne vulgaris: a randomized, controlled clinical trial. Clinical drug investigation 2017; 37: 1083-91.
  • Bhansali S, Dutta P, Kumar V, et al. Efficacy of autologous bone marrow-derived mesenchymal stem cell and mononuclear cell transplantation in type 2 diabetes mellitus: a randomized, placebo-controlled comparative study. Stem cells and development 2017; 26(7): 471-81.
  • Hota D, Srinivasan A, Dutta P, Bhansali A, Chakrabarti A. Off-label, low-dose naltrexone for refractory painful diabetic neuropathy. Pain medicine 2016; 17(4): 790-1.
  • Dutta P, Korbonits M, Sachdeva N, et al. Can immediate postoperative random growth hormone levels predict long-term cure in patients with acromegaly? Neurology India 2016; 64(2): 252-8.
  • Syal K, Srinivasan A, Banerjee D. VDR, RXR, coronin-1 and interferonγ levels in PBMCs of type-2 diabetes patients: molecular link between diabetes and tuberculosis. Indian Journal of Clinical Biochemistry 2015; 30: 323-8.
  • Singh I, Achuthan S, Chakrabarti A, Rajagopalan S, Srinivasan A, Hota D. Influence of pre‐operative use of serotonergic antidepressants (SADs) on the risk of bleeding in patients undergoing different surgical interventions: a meta‐analysis. Pharmacoepidemiology and drug safety 2015; 24(3): 237-45.
  • Rajagopalan S, Dutta P, Hota D, Bhansali A, Srinivasan A, Chakrabarti A. Effect of low dose pioglitazone on glycemic control and insulin resistance in Type 2 diabetes: A randomized, double blind, clinical trial. Diabetes research and clinical practice 2015; 109(3): e32-e5.
  • Mukherjee KK, Dhandapani S, Sarda AC, et al. Prospective comparison of simple suturing and elevation debridement in compound depressed fractures with no significant mass effect. Acta neurochirurgica 2015; 157: 305-9.
  • Dutta P, Mahendran B, Reddy KS, et al. Short-term efficacy of recombinant human GH therapy in cured acromegaly patients with GH deficiency: a single-center experience. Endocrine connections 2015; 4(1): 65.
  • Dutta P, Kamath SS, Bhalla A, et al. Effects of acute organophosphate poisoning on pituitary target gland hormones at admission, discharge and three months after poisoning: A hospital based pilot study. Indian journal of endocrinology and metabolism 2015; 19(1): 116-23.
  • Dutta P, Gupta P, Singh P, et al. Extra-pituitary birth defects may predict diagnosis of congenital hypopituitarism in a short child. The Journal of the Association of Physicians of India 2015; 63(8): 28-36.
  • Achuthan S, Singh I, Varthya SB, Srinivasan A, Chakrabarti A, Hota D. Gabapentin prophylaxis for postoperative nausea and vomiting in abdominal surgeries: a quantitative analysis of evidence from randomized controlled clinical trials. British journal of anaesthesia 2015; 114(4): 588-97.
  • Singh I, Srinivasan A. Higher risk of low birth weight and preterm delivery associated with antidepressant exposure: are we in the right direction? General hospital psychiatry 2014; 36(3): 358.
  • Mukherjee KK, Dutta P, Singh A, et al. Choice of fluid therapy in patients of craniopharyngioma in the perioperative period: A hospital-based preliminary study. Surgical neurology international 2014; 5: 105.
  • Kaur S, Rajagopalan S, Shafiq N, et al. Drugs Implicated, Mortality and Use of Corticosteroids in Toxic Epidermal Necrolysis Cases: A Systematic Review of Published Case Reports and Case Series. Journal of Postgraduate Medicine, Education and Research 2014; 48(3): 132-8.
  • Silencing of high‐mobility group box 2 (HMGB2) modulates cisplatin and 5‐fluorouracil sensitivity in head and neck squamous cell carcinoma. Proteomics 2014.
  • Host response profile of human brain proteome in toxoplasma encephalitis co-infected with HIV. Clinical proteomics 2014; 11(1): 1-13.
  • Syal K, Srinivasan A, Banerjee D. Streptomycin interference in Jaffe reaction—possible false positive creatinine estimation in excessive dose exposure. Clinical biochemistry 2013; 46(1-2): 177-9.
  • Syal K, Banerjee D, Srinivasan A. Creatinine estimation and interference. Indian Journal of Clinical Biochemistry 2013; 28: 210-1.
  • Srinivasan A, Syal K, Banerjee D, et al. Low plasma levels of cholecalciferol and 13-cis-retinoic acid in tuberculosis: implications in host-based chemotherapy. Nutrition (Burbank, Los Angeles County, Calif) 2013; 29(10): 1245-51.
  • Singh I, Rajagopalan S, Srinivasan A, et al. Preoperative statin therapy is associated with lower requirement of renal replacement therapy in patients undergoing cardiac surgery: a meta-analysis of observational studies. Interactive cardiovascular and thoracic surgery 2013; 17(2): 345-52.
  • Lata K, Dutta P, Sridhar S, et al. Thyroid autoimmunity and obstetric outcomes in women with recurrent miscarriage: a case–control study. Endocrine connections 2013; 2(2): 118-24.
  • Dhamija P, Bansal D, Srinivasan A, Bhalla A, Hota D, Chakrabarti A. Patterns of prescription drug use and incidence of drug–drug interactions in patients reporting to medical emergency. Fundamental & clinical pharmacology 2013; 27(2): 231-7.
  • Singh PK, Hota D, Dutta P, et al. Pantoprazole improves glycemic control in type 2 diabetes: a randomized, double-blind, placebo-controlled trial. The Journal of Clinical Endocrinology & Metabolism 2012; 97(11): E2105-E8.
  • Dutta P, Mukherjee KK, Chaudhary PK, et al. Pituitary dysfunction in survivors of spontaneous subarachnoid hemorrhage of anterior communicating artery and middle cerebral artery aneurysms: A comparative study. Neurology India 2012; 60(4): 390.

Dr. Anand Srinivasan

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EXPERTISE INFORMATION
Areas of Interest
    • Artificial Intelligence
    • Precision Medicine
    • Computational Medicine
    • Pharmacometrics and Clinical Trials